Why Rejuran (Salmon Sperm Facial) Is a Course, Not a Single Session

Rejuran is given as a course, not a one-off. At The Aesthetic Edge that is typically two to four sessions spaced two to four weeks apart, because polynucleotides do not fill or plump — they signal your skin's own repair processes, and that response builds gradually over the weeks after each session. One session starts something. The course is what lets it accumulate.

That single fact explains most of the disappointment people report after trying this treatment once, somewhere, and concluding it did nothing. It is also the fact that a well-run consultation covers before anyone books anything.

Why can this not be done in one appointment?

Because nothing is being placed to occupy space. A dermal filler is a gel put under the skin to add volume or contour, and you can see the change the moment it is placed, because the change is the gel. Polynucleotides add no volume at all. The purified DNA fragments are micro-injected into the skin, where they act as a signal that prompts your skin's own repair and regeneration processes. The improvement you eventually see — hydration, elasticity, texture, fine lines — is produced by your skin, not by a product sitting in it.

Biology takes its own time, and it does not read your calendar. So the honest description of session one is that it starts a process whose visible part arrives over the following weeks. Someone who books a single appointment expecting a next-day change has been sold the wrong picture of the treatment, not given the wrong treatment.

How far apart are the sessions, and why that gap?

Two to four weeks. The gap exists so that each session lands on skin that has already begun responding to the last one, rather than on skin still settling from it, and so that the doctor can see what your skin actually did before deciding what to do next.

That review is not a formality. Sessions are reviewed each visit, which is the point at which the plan can change — the number of sessions, the areas treated, or the decision that a different treatment would serve you better.

What actually changes between the first session and the last?

Gradually: hydration, bounce and a healthier-looking surface, building across the course rather than arriving overnight. Patients most often describe it as skin that looks less tired and behaves better, rather than a face that looks different. Your features are unchanged, because nothing has been placed to plump, lift or contour.

One honest caveat belongs here, and it is the same one we put on the treatment page itself: this is a newer treatment and the evidence base is still building. Early studies and clinical experience are encouraging for hydration, elasticity and fine lines, but long-term comparative data is more limited than for older treatments. An outcome cannot be promised, and anyone promising you one is describing marketing rather than medicine.

Will two sessions be enough, or will I need four?

That is settled at the consultation and revisited at each visit, not decided by a blog post. The range exists precisely because the answer varies — with the concern being treated, the area, and how your skin responds to the first session. A doctor who has examined your skin can give you a plan; a number quoted before anyone has looked at you is a guess wearing a uniform.

When is a pre-paid package a warning sign?

When it is sold to you before anyone has assessed your skin. That is the sequence worth protecting. At a proper consultation the doctor examines your skin, confirms polynucleotides actually suit the concern, and screens for the things that rule injecting out — a known fish or product allergy, active skin infection or open wounds in the area, certain skin conditions, and pregnancy or breastfeeding. Rejuran is derived from salmon, so any fish allergy needs raising specifically.

A package bought before that assessment commits your money to a treatment that may turn out not to be the right one for you. If your main concern is volume loss, sagging or deep folds, polynucleotides are the wrong tool entirely, and a doctor should say so rather than sell you a block of sessions.

Two other things are worth noticing on any package offer. First, the session count: a documented course here is two to four sessions, so a block of eight or ten sold up front is worth asking hard questions about. Second, whether the plan can change after a review — if it cannot, the review is decorative.

None of this means a course cannot be planned or paid for sensibly. It means the assessment comes first and the plan comes second, in that order.

What if I want to stop partway through?

Say so, and have the conversation with the doctor rather than simply not rebooking. Nothing that has already been done is undone by stopping, but a part-course and a full course are different plans with different expectations, and it is better to change the plan deliberately than to abandon it and conclude the treatment failed.

What does a course cost?

We do not publish a figure for this treatment, because the honest answer depends on the number of sessions your skin actually needs and the area being treated — and both of those are decided after an assessment, not before. What we can tell you plainly is the entry point: the consultation is ₹500, waived off against treatment. You will get the plan and the cost of that plan in writing before anything is injected.

What should make you ring the clinic between sessions?

Small injection-point bumps, redness, tenderness and mild swelling are expected after each session and usually settle within 24 to 48 hours. Bruising at an injection point is possible and typically clears within a few days.

What should prompt a phone call rather than a wait-and-see is increasing pain, heat, spreading redness, or any reaction you did not expect — ring the clinic promptly rather than waiting for your next scheduled session. Please do not try to work out for yourself whether it is serious; that assessment is ours to make, and we would far rather look at something that turns out to be nothing. If it is out of hours and you are worried about how quickly something is changing, seek medical care locally rather than waiting for us to open.

Where to start

If you are weighing this against a hydrating treatment, the comparison worth having is with skin boosters and Profhilo, which are hyaluronic acid and work by holding water in the skin — a different mechanism for a different problem. Which suits you depends on whether your main issue is dryness or overall skin quality, and that is a consultation question.

Book an appointment and come with your questions about the course, not just the treatment. The plan is the part that decides whether you are happy in three months.